Living with arthritis can mean living with chronic pain. This pain can make you tired and depressed, and that slump can persist even on “good days” when the pain isn’t so bad.

See Recognizing Rheumatoid Arthritis (RA) Fatigue

You may feel less motivated to do chores, like making dinner, or to do things you once enjoyed, like playing a round of golf with friends.

Chronic pain can cause suffering, which is the emotional experience of coping with pain.
Suffering and Chronic Pain

Scientists recognize this cycle of behavior, too, and have begun asking why. The answer may lie in the brain’s chemistry.

As reported in Science, researchers conducted a series of experiments that show mice in chronic pain are less motivated than their pain-free peers to seek food, even after the pain is relieved with medication.1

These experiments accounted for how pain might affect appetite and mobility. So what was the difference between the healthy mice and the mice in chronic pain?


Researchers studied the brains in both groups of mice. Specifically, they looked at a part of the brain called the nucleus accumbens, which influences motivation and behavior, prodding us to seek out or avoid certain stimuli. The nucleus accumbens were different in the two groups of mice, and that difference was attributed to a neuropeptide called galanin. (Neuropeptides are molecules that transmit information between the brain’s neurons, or nerve cells. A more commonly known neuropeptide is endorphin.)

See How Rheumatoid Arthritis (RA) Causes Fatigue

For the mice in chronic pain, galanin suppressed pathways of activity in the nucleus accumbens. This suppression likely sapped the mice of their motivation to work for food. Moreover, this suppression didn’t go away; the affects on the brain endured even when the chronic pain disappeared.

See Suffering and Chronic Pain

Of course, scientists are not ready to generalize these findings to humans, and more research is needed. The causes of fatigue, depression, and emotional distress caused by chronic pain are complicated and intertwined.

However, this study brings hope that we may some day be able to alleviate some symptoms of fatigue by adjusting the chemical reactions that cause chronic pain to sap motivation.

In addition, there are some self-care and lifestyle changes you can make to help combat the fatigue that often accompanies chronic pain:

Learn more:

Coping with Chronic Pain and Insomnia

12 Ways to Cope with Chronic Pain and Depression