Painful inflammation, swelling, and stiffness in the knuckles and wrists can be signs of rheumatoid arthritis. Simple tasks such as opening a jar or turning a key can become difficult.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. RA symptoms appear in the hand when the immune system mistakenly attacks joint tissues in the fingers, thumb, and/or wrist.

Inflammation, swelling, and stiffness in the knuckles and wrists can be the first signs of RA.

How Rheumatoid Arthritis Affects Hand Function

Experts estimate 90% of people who have RA have symptoms in at least one hand joint.1,2 Hand dexterity, grip strength, and the ability to pinch objects between the thumb and fingers are likely to be affected.3,4 People may notice their grip strength is even weaker when RA inflammation levels are high.3,4

Problems with hand function tend to be the result of RA joint damage.5 This damage can weaken tendons and cause joints to be malaligned or deformed. A significant amount of joint damage happens early on in the disease process, which is why early diagnosis and treatment is important.

See Blood Tests to Help Diagnose Rheumatoid Arthritis (RA)

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Hand Joints Most Affected By Rheumatoid Arthritis

Of the 27 joints6 in a hand, the joints most likely to show signs of RA include:

  • The metacarpophalangeal (MCP) joints, or large knuckles, where the fingers and thumb meet the hand
  • The proximal interphalangeal (PIP) joints, or middle knuckles
  • The joints of the wrist that connect the wrist’s eight carpal bones with each other and the bones of the forearm (the radius and ulna), including the carpometacarpal joint, midcarpal joint, radiocarpal joint, and intercarpal joints

The distal interphalangeal (DIP) joints, the joints closest to the tips of the fingers and thumb, are less likely to be affected by rheumatoid arthritis. When DIP joints are affected, it is typically only after symptoms appear in the MCP or PIP joints. It is more common for DIP joints to be affected by osteoarthritis than by RA.

See Recognizing Osteoarthritis in the Hand

Hand joints are synovial joints
The small joints of the hands are an example of synovial joints. (Most flexible joints in the body, including the knees, hips, and shoulders, are also synovial joints.) Rheumatoid arthritis attacks synovial joints.

  • Each synovial joint is encapsulated in a pliable membrane, called a synovial membrane or synovium. When the joint is healthy, this membrane is very thin—just one or two cells thick.
  • The joint capsule contains synovial fluid. This fluid is produced by the membrane. It is thin, clear, and viscous, and it normally nourishes and lubricates the joint, enabling movement.

Synovial joints in the hand are quite small and normally contain just a tiny amount of synovial fluid.

See How Do Synovial Joints Work?

How Rheumatoid Arthritis Develops

When rheumatoid arthritis occurs, the immune system attacks a synovial joint’s delicate membrane. The affected finger, thumb, and/or wrist joints can become inflamed, swollen, and painful.

The disease process involves these 5 steps:

  1. White blood cells invade. The immune system sends white blood cells, called leukocytes, to invade one or more hand joints.
  2. Inflammation is triggered. The white blood cells trigger inflammation in the hand joints’ synovium. When synovium is inflamed it is called synovitis.
  3. Pannus forms. The inflamed synovial tissue may continue to react to the white blood cell invasion by adding layers of new synovial cells at a very rapid pace. This new, abnormal tissue is called pannus.
  4. Cartilage and bone are damaged. The rheumatoid pannus tissue squeezes into the joint space between bones and releases proteins that degrade the hand joints’ articular cartilage, ligaments, and bone.
  5. Excess fluid is produced. In addition to releasing damaging proteins, the pannus may create excess fluid that contributes to wrist and knuckle swelling.

Changes can also occur in the hand’s tendons.

Tenosynovitis in the Hands

In addition to encapsulating joints, synovial tissue also surrounds most tendons. Tendons connect muscles to bones. Rheumatoid arthritis can cause a tendon’s synovial sheath to become inflamed, a condition called tenosynovitis. The inflammation is not always painful but can lead to tendon damage.

In the hand, flexor tendons allow a person to bend their fingers. When a flexor tendon is inflamed it can cause the PIP joint to get stuck in a bent position, a condition called trigger finger.

At least one study suggests that tenosynovitis of flexor tendons is a strong predictor of rheumatoid arthritis.7

Hand tenosynovitis from rhuematoid arthritis. Read Trigger Finger (Stenosing Tenosynovitis)

How RA Causes Hand Pain

Changes to the hand joint can be seen and felt. Inflammation can cause significant pain, swelling, and stiffness. In addition, joint degeneration and abnormalities can put excess strain on already damaged tendons and other tissues, leading to pain.

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When Rheumatoid Arthritis in the Hand Is Serious

Over time, damage to joint tissues can cause bones to become malaligned. This malalignment can result in hand deformities and prevent the hand from functioning normally.

RA in the hand can be a serious cause for concern if it prevents a person from being able to care for themselves, particularly if they live alone. It can also be serious if it leads to severe carpal tunnel syndrome. Advanced carpal tunnel causes numbness and/or tingling and weakness in the thumb and associated fingers, and can result in permanent nerve damage if left untreated. In either of these cases, consultation with a medical professional is advised.

References

  • 1.Flemming A, Benn RT, Corbett M, Wood PH. Early rheumatoid disease. II. Patterns of joint involvement. Ann Rheum Dis. 1976;35:361–364. doi: 10.1136/ard.35.4.361
  • 2.Wæhrens EE, Bliddal H, Danneskiold-Samsoe B, Lund H, Fisher AG. Differences between questionnaire- and interview-based measures of ADL ability and the association to observed ADL ability in women with rheumatoid arthritis, knee osteoarthritis and fibromyalgia. Scand J Rheumatol. 2012;41:95–102. As cited in Ellegaard K, von Bülow C, Røpke A, et al. Hand exercise for women with rheumatoid arthritis and decreased hand function: an exploratory randomized controlled trial. Arthritis Res Ther. 2019;21(1):158. Published 2019 Jun 26. doi:10.1186/s13075-019-1924-9
  • 3.Palamar D, Er G, Terlemez R, Ustun I, Can G, Saridogan M. Disease activity, handgrip strengths, and hand dexterity in patients with rheumatoid arthritis. Clin Rheumatol. 2017;36(10):2201‐2208. doi:10.1007/s10067-017-3756-9
  • 4.Higgins SC, Adams J, Hughes R. Measuring hand grip strength in rheumatoid arthritis. Rheumatol Int. 2018;38(5):707‐714. doi:10.1007/s00296-018-4024-2
  • 5.Vliet Vlieland TP, van der Wijk TP, Jolie IM, Zwinderman AH, Hazes JM. Determinants of hand function in patients with rheumatoid arthritis. J Rheumatol. 1996;23(5):835‐840.
  • 6.Sharp JT, Young DY, Bluhm GB, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?. Arthritis Rheum. 1985;28(12):1326‐1335. doi:10.1002/art.1780281203
  • 7.Eshed I, Feist E, Althoff CE, et al. Tenosynovitis of the flexor tendons of the hand detected by MRI: an early indicator of rheumatoid arthritis Rheumatology (2009) 48 (8): 887-891 first published online May 27, 2009 doi:10.1093/rheumatology/kep136
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